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KMID : 0882420090760060752
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Korean Journal of Medicine
2009 Volume.76 No. 6 p.752 ~ p.757
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A TSH-secreting pituitary microadenoma diagnosed with inferior petrosal sinus sampling: Case report
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Sung Joong-Kyung
Shin Young-Goo
Chung Choon-Hee
Nam Soo-Min
Whang Kum
Kim Eun-Mi
Koh Jang-Hyun
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Abstract
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Thyroid stimulating hormone (TSH)-secreting pituitary adenomas are rare tumors of the pituitary gland and represent 1~2% of all pituitary adenomas. A TSH-secreting pituitary adenoma shows as a normal or elevated thyrotropin level in a hyperthyroid patient. We present a 32-year-old woman who was diagnosed with a TSH-secreting pituitary microadenoma. She had a high free T4, with a normal TSH and α-subunit. Bilateral inferior petrosal sinus sampling (IPSS) was done to confirm the α-subunit secreting adenoma, and the concentration of the α-subunit was high on the tumor side. The pituitary microadenoma was removed, and her TSH and free T4 levels decreased to normal. IPSS may help give an accurate diagnosis in the patient with a normal α-subunit.
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KEYWORD
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α-Subunit, Inferior petrosal sinus sampling, Pituitary microadenoma, TSH
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